› 2vph

X-ray diffraction
1.9Å resolution

Crystal structure of the human protein tyrosine phosphatase, non- receptor type 4, PDZ domain

Released:
DOI: 10.2210/pdb2vph/pdb
PDB entry 2vph coloured by chain, front view.
PDB entry 2vph coloured by chain, side view.
PDB entry 2vph coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Roos AK, Wang J, Burgess-Brown N, Elkins JM, Kavanagh K, Pike ACW, Filippakopoulos P, Arrowsmith CH, Weigelt J, Edwards A, von Delft F, Bountra C, Knapp S

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29074 (Residues: 513-610; Coverage: 11%)
Gene name: PTPN4
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 36.489Å b: 71.015Å c: 71.598Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.243
Expression system: Escherichia coli BL21(DE3)

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