› 2vpf

X-ray diffraction
1.93Å resolution

VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb2vpf/pdb
PDB entry 2vpf coloured by chain, front view.
PDB entry 2vpf coloured by chain, side view.
PDB entry 2vpf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Muller YA, Christinger HW, Keyt BA, de Vos AM
Structure 5 1325-38 (1997)
PMID: 9351807

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147429 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-VEGF Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 102 amino acids
Theoretical weight: 11.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 214-315; Coverage: 26%)
Gene names: VEGF, VEGFA
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P1
Unit cell:
a: 45.47Å b: 68.47Å c: 85.82Å
α: 105.44° β: 93.71° γ: 101.49°
R-values:
R R work R free
0.209 0.209 0.272
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Vascular endothelial growth factor (VEGF) and its receptors.
Neufeld et al. (1999)
20 more

27 mentions without citation

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications.
Spicer et al. (2018)
26 more