2vo0 Summary

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STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-(4-(4-CHLOROPHENYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN-4-YL)METHYLAMINE

The structure was published by Caldwell, J.J., Davies, T.G., Donald, A., et al., Workman, P., Garrett, M.D., and Collins, I., in 2008 in a paper entitled "Identification of 4-(4-Aminopiperidin-1-Yl)-7H-Pyrrolo[2,3-D]Pyrimidines as Selective Inhibitors of Protein Kinase B Through Fragment Elaboration." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.94 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNITPROTE and CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNITPROTE P00517 (1-351) (KAPCA_BOVIN)search Bos taurussearch 96% 351 97%
I CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA P61925 (6-25) (IPKA_HUMAN)search Homo sapienssearch 100% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (1 - 351) CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNITPROTE Bos taurus
P61925 (6 - 25) CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA HOMO SAPIENS

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00517) protein phosphorylationsearch regulation of proteasomal protein catabolic processsearch regulation of tight junction assemblysearch cellular response to parathyroid hormone stimulussearch peptidyl-serine phosphorylationsearch peptidyl-threonine phosphorylationsearch phosphorylationsearch regulation of synaptic transmissionsearch sperm capacitationsearch regulation of osteoblast differentiationsearch positive regulation of protein export from nucleussearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch regulation of protein processingsearch neural tube closuresearch cellular response to glucose stimulussearch positive regulation of cell cycle arrestsearch mesoderm formationsearch protein autophosphorylationsearch protein serine/threonine kinase activitysearch protein kinase A regulatory subunit bindingsearch protein kinase activitysearch protein bindingsearch protein kinase bindingsearch ATP bindingsearch protein serine/threonine/tyrosine kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch cAMP-dependent protein kinase activitysearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch sperm midpiecesearch membranesearch plasma membranesearch cytoplasmsearch neuromuscular junctionsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch centrosomesearch ciliary basesearch AMP-activated protein kinase complexsearch
I (P61925) negative regulation of protein kinase activitysearch cAMP-dependent protein kinase inhibitor activitysearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch