› 2vns

X-ray diffraction
2Å resolution

Crystal Structure of the Membrane Proximal Oxidoreductase Domain of Human Steap3, the Dominant Ferric Reductase of the Erythroid Transferrin Cycle

Released:
DOI: 10.2210/pdb2vns/pdb
PDB entry 2vns coloured by chain, front view.
PDB entry 2vns coloured by chain, side view.
PDB entry 2vns coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle.
Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM
Proc Natl Acad Sci U S A 105 7410-5 (2008)
PMID: 18495927

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179191 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metalloreductase STEAP3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q658P3 (Residues: 1-215; Coverage: 44%)
Gene names: STEAP3, TSAP6
Sequence domains: NADP oxidoreductase coenzyme F420-dependent
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 37.686Å b: 66.812Å c: 143.366Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.
Richardson et al. (2010)
22 more

5 mentions without citation

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle.
Sendamarai et al. (2008)
4 more