2vl4 Summary



The structure was published by Tailford, L.E., Offen, W.A., Smith, N.L., et al., Vasella, A., Gilbert, H.J., and Davies, G.J., in 2008 in a paper entitled "Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of BETA-MANNOSIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-MANNOSIDASE Q8AAK6 (26-864) (Q8AAK6_BACTN)search Bacteroides thetaiotaomicron VPI-5482search 97% 846 99%
B BETA-MANNOSIDASE Q8AAK6 (26-864) (Q8AAK6_BACTN)search Bacteroides thetaiotaomicron VPI-5482search 97% 846 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8AAK6 (26 - 864) BETA-MANNOSIDASE Bacteroides thetaiotaomicron VPI-5482

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B beta-Galactosidase/glucuronidase domainsearch, beta-Galactosidase/glucuronidase, N-terminal domainsearch, beta-glycanasessearch Glycosyl hydrolases family 2search, Glycosyl hydrolases family 2, TIM barrel domainsearch, Glycosyl hydrolases family 2, sugar binding domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q8AAK6) hydrolase activity, hydrolyzing O-glycosyl compoundssearch beta-mannosidase activitysearch carbohydrate metabolic processsearch mannan catabolic processsearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwichsearch Glycoside hydrolase, family 2, TIM barrelsearch Glycosyl hydrolases family 2, sugar binding domainsearch Galactose-binding domain-likesearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domainsearch Glycoside hydrolase superfamilysearch Beta mannosidasesearch