2vkz Summary

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STRUCTURE OF THE CERULENIN-INHIBITED FUNGAL FATTY ACID SYNTHASE TYPE I MULTIENZYME COMPLEX

The structure was published by Johansson, P., Wiltschi, B., Kumari, P., et al., Vonck, J., Oesterhelt, D., and Grininger, M., in 2008 in a paper entitled "Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely FATTY ACID SYNTHASE SUBUNIT ALPHA and FATTY ACID SYNTHASE SUBUNIT BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FATTY ACID SYNTHASE SUBUNIT ALPHA P19097 (1-1887) (FAS2_YEAST)search Saccharomyces cerevisiae S288csearch 100% 1887 85%
B FATTY ACID SYNTHASE SUBUNIT ALPHA P19097 (1-1887) (FAS2_YEAST)search Saccharomyces cerevisiae S288csearch 100% 1887 85%
C FATTY ACID SYNTHASE SUBUNIT ALPHA P19097 (1-1887) (FAS2_YEAST)search Saccharomyces cerevisiae S288csearch 100% 1887 85%
G FATTY ACID SYNTHASE SUBUNIT BETA P07149 (1-2051) (FAS1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 2051 99%
H FATTY ACID SYNTHASE SUBUNIT BETA P07149 (1-2051) (FAS1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 2051 99%
I FATTY ACID SYNTHASE SUBUNIT BETA P07149 (1-2051) (FAS1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 2051 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19097 (1 - 1887) FATTY ACID SYNTHASE SUBUNIT ALPHA Saccharomyces cerevisiae
P07149 (1 - 2051) FATTY ACID SYNTHASE SUBUNIT BETA Saccharomyces cerevisiae

Chain Sequence family (Pfam)
A, B, C (P19097) PF00109: Beta-ketoacyl synthase, N-terminal domainsearch, PF01648: 4'-phosphopantetheinyl transferase superfamilysearch, PF02801: Beta-ketoacyl synthase, C-terminal domainsearch, PF13561: Enoyl-(Acyl carrier protein) reductasesearch
G, H, I (P07149) PF00698: Acyl transferase domainsearch, PF01575: MaoC like domainsearch, PF08354: Domain of unknown function (DUF1729)search, PF13452: N-terminal half of MaoC dehydratasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (P19097) catalytic activitysearch magnesium ion bindingsearch transferase activitysearch oxidoreductase activitysearch holo-[acyl-carrier-protein] synthase activitysearch 3-oxoacyl-[acyl-carrier-protein] synthase activitysearch fatty acid synthase activitysearch 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activitysearch protein bindingsearch fatty-acyl-CoA synthase activitysearch metal ion bindingsearch metabolic processsearch macromolecule biosynthetic processsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch oxidation-reduction processsearch long-chain fatty acid biosynthetic processsearch lipid metabolic processsearch fatty acid synthase complexsearch cytosolsearch
G, H, I (P07149) oxidoreductase activitysearch transferase activitysearch enoyl-[acyl-carrier-protein] reductase (NADH) activitysearch fatty acid synthase activitysearch palmitoyltransferase activitysearch [acyl-carrier-protein] S-malonyltransferase activitysearch [acyl-carrier-protein] S-acetyltransferase activitysearch palmitoyl-[acyl-carrier-protein] hydrolase activitysearch oleoyl-[acyl-carrier-protein] hydrolase activitysearch enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activitysearch acyl-[acyl-carrier-protein] hydrolase activitysearch 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activitysearch myristoyl-[acyl-carrier-protein] hydrolase activitysearch hydrolase activitysearch 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activitysearch protein bindingsearch catalytic activitysearch fatty-acyl-CoA synthase activitysearch lyase activitysearch oxidation-reduction processsearch fatty acid biosynthetic processsearch metabolic processsearch fatty acid metabolic processsearch lipid metabolic processsearch long-chain fatty acid biosynthetic processsearch cytosolsearch fatty acid synthase complexsearch lipid particlesearch

Chain InterPro annotation
A, B, C Acyl transferase domainsearch Holo-[acyl carrier protein] synthasesearch Phosphopantethiene-protein transferase domainsearch 4'-phosphopantetheinyl transferase superfamilysearch Beta-ketoacyl synthase, N-terminalsearch Beta-ketoacyl synthase, C-terminalsearch Acyl transferase/acyl hydrolase/lysophospholipasesearch Thiolase-like, subgroupsearch Thiolase-likesearch NAD(P)-binding domainsearch Beta-ketoacyl synthase, active sitesearch Fatty acid synthase alpha subunit, yeastsearch
G, H, I Acyl transferase domainsearch MaoC-like domainsearch Fatty acid synthasesearch Domain of unknown function DUF1729search Acyl transferasesearch Acyl transferase/acyl hydrolase/lysophospholipasesearch Fatty acid synthase, beta subunit, fungisearch HotDog domainsearch