2vj3 Summary



The structure was published by Cordle, J., Johnson, S., Tay, J.Z., et al., Baron, M., Lea, S.M., and Handford, P.A., in 2008 in a paper entitled "A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 P46531 (411-526) (NOTC1_HUMAN)search Homo sapienssearch < 90% 135 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P46531 (411 - 526) NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A EGF-type modulesearch EGF-like domainsearch, Calcium-binding EGF domainsearch

Chain ID Molecular function (GO)
A (P46531) calcium ion bindingsearch

Chain InterPro annotation
A EGF-type aspartate/asparagine hydroxylation sitesearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch Insulin-like growth factor binding protein, N-terminalsearch EGF-like, conserved sitesearch EGF-like calcium-binding, conserved sitesearch