2vgp Summary



The structure was published by Andersen, C.B., Wan, Y., Chang, J.W., et al., Heald, R., Musacchio, A., and Gray, N.S., in 2008 in a paper entitled "Discovery of Selective Aminothiazole Aurora Kinase Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SERINE/THREONINE-PROTEIN KINASE 12-A and INNER CENTROMERE PROTEIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE 12-A Q6DE08 (78-361) (AUKBA_XENLA)search Xenopus laevissearch < 90% 284 97%
B SERINE/THREONINE-PROTEIN KINASE 12-A Q6DE08 (78-361) (AUKBA_XENLA)search Xenopus laevissearch < 90% 284 97%
C INNER CENTROMERE PROTEIN A O13024 (798-840) (INCEA_XENLA)search Xenopus laevissearch < 90% 43 100%
D INNER CENTROMERE PROTEIN A O13024 (798-840) (INCEA_XENLA)search Xenopus laevissearch < 90% 43 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q6DE08 (78 - 361) SERINE/THREONINE-PROTEIN KINASE 12-A Xenopus laevis
O13024 (798 - 840) INNER CENTROMERE PROTEIN A Xenopus laevis

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
C, D Inner centromere protein, ARK binding regionsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q6DE08) chromosome passenger complexsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch positive regulation of cytokinesissearch mitotic nuclear divisionsearch spindle checkpointsearch histone H3-S28 phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Aurora kinase Bsearch
C, D Inner centromere protein, ARK-binding domainsearch