2vcq Summary

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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.

The structure was published by Hohwy, M., Spadola, L., Lundquist, B., et al., Von Wachenfeldt, K., Folmer, R.H.A., and Edman, K., in 2008 in a paper entitled "Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 199 99%
B GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 199 99%
C GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 199 99%
D GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 199 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60760 (1 - 199) GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (O60760) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (O60760) cyclooxygenase pathwaysearch glutathione derivative biosynthetic processsearch prostaglandin metabolic processsearch signal transductionsearch lipid metabolic processsearch prostaglandin biosynthetic processsearch xenobiotic metabolic processsearch small molecule metabolic processsearch arachidonic acid metabolic processsearch fatty acid metabolic processsearch fatty acid biosynthetic processsearch locomotory behaviorsearch calcium ion bindingsearch isomerase activitysearch transferase activitysearch prostaglandin-D synthase activitysearch protein homodimerization activitysearch magnesium ion bindingsearch metal ion bindingsearch glutathione transferase activitysearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A, B, C, D Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch