2v9t

X-ray diffraction
1.7Å resolution

Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into the Slit-Robo complex.
Proc Natl Acad Sci U S A 104 14923-8 (2007)
PMID: 17848514

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-131763 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Roundabout homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y6N7 (Residues: 58-166; Coverage: 7%)
Gene names: DUTT1, ROBO1
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
Slit homolog 2 protein N-product Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 24.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94813 (Residues: 271-484; Coverage: 14%)
Gene names: SLIL3, SLIT2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 51.27Å b: 190.09Å c: 40.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.226
Expression system: Homo sapiens