2v7a Summary

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CRYSTAL STRUCTURE OF THE T315I ABL MUTANT IN COMPLEX WITH THE INHIBITOR PHA-739358

The structure was published by Modugno, M., Casale, E., Soncini, C., et al., Cameron, A.D., Isacchi, A., and Moll, J., in 2007 in a paper entitled "Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 286 94%
B PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 286 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (229 - 512) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00519) protein tyrosine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch