complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284
The structure was published by Apsel, B., Blair, J.A., Gonzalez, B., et al., Williams, R.L., Shokat, K.M., and Knight, Z.A., in 2008 in a paper entitled "Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM. This molecule has the UniProt identifier P48736 (PK3CG_HUMAN). The sample contained 966 residues which is < 90% of the natural sequence. Out of 966 residues 844 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: