2v01 Summary



The structure was published by Kursula, P. and Majava, V., in 2007 in a paper entitled "A Structural Insight Into Lead Neurotoxicity and Calmodulin Activation by Heavy Metals." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CALMODULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62158) calcium ion bindingsearch protein bindingsearch phospholipase bindingsearch ion channel bindingsearch protein domain specific bindingsearch titin bindingsearch metal ion bindingsearch thioesterase bindingsearch phosphatidylinositol 3-kinase bindingsearch adenylate cyclase bindingsearch nitric-oxide synthase bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein N-terminus bindingsearch nitric-oxide synthase regulator activitysearch enzyme regulator activitysearch calcium-dependent protein bindingsearch protein phosphatase activator activitysearch N-terminal myristoylation domain bindingsearch nitric oxide metabolic processsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch glycogen catabolic processsearch regulation of cytokinesissearch membrane organizationsearch regulation of ryanodine-sensitive calcium-release channel activitysearch response to calcium ionsearch response to corticosteronesearch neurotrophin TRK receptor signaling pathwaysearch synaptic transmissionsearch positive regulation of protein dephosphorylationsearch small molecule metabolic processsearch regulation of high voltage-gated calcium channel activitysearch regulation of rhodopsin mediated signaling pathwaysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch muscle contractionsearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of phosphoprotein phosphatase activitysearch rhodopsin mediated signaling pathwaysearch regulation of nitric-oxide synthase activitysearch calcium-mediated signalingsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch substantia nigra developmentsearch platelet activationsearch regulation of heart ratesearch blood coagulationsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of nitric-oxide synthase activitysearch activation of adenylate cyclase activitysearch inositol phosphate metabolic processsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch Fc-epsilon receptor signaling pathwaysearch platelet degranulationsearch epidermal growth factor receptor signaling pathwaysearch G-protein coupled receptor signaling pathwaysearch phototransduction, visible lightsearch activation of phospholipase C activitysearch glucose metabolic processsearch response to amphetaminesearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch innate immune responsesearch regulation of cardiac muscle contractionsearch carbohydrate metabolic processsearch signal transductionsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch detection of calcium ionsearch cytosolsearch nucleussearch spindle polesearch cytoplasmsearch plasma membranesearch extracellular vesicular exosomesearch neuron projectionsearch growth conesearch nucleoplasmsearch extracellular regionsearch calcium channel complexsearch spindlesearch spindle microtubulesearch sarcomeresearch cytoskeletonsearch centrosomesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch