2v01 Summary



The structure was published by Kursula, P. and Majava, V., in 2007 in a paper entitled "A Structural Insight Into Lead Neurotoxicity and Calmodulin Activation by Heavy Metals." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CALMODULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62158) calcium ion bindingsearch adenylate cyclase bindingsearch protein bindingsearch protein domain specific bindingsearch N-terminal myristoylation domain bindingsearch phosphatidylinositol 3-kinase bindingsearch protein phosphatase activator activitysearch nitric-oxide synthase regulator activitysearch titin bindingsearch calcium-dependent protein bindingsearch phospholipase bindingsearch protein kinase bindingsearch ion channel bindingsearch type 3 metabotropic glutamate receptor bindingsearch metal ion bindingsearch protein serine/threonine kinase activator activitysearch thioesterase bindingsearch enzyme regulator activitysearch nitric-oxide synthase bindingsearch protein N-terminus bindingsearch cytosolsearch sarcomeresearch extracellular vesicular exosomesearch spindle microtubulesearch spindlesearch plasma membranesearch centrosomesearch spindle polesearch cytoplasmsearch nucleussearch cytoskeletonsearch nucleoplasmsearch growth conesearch vesiclesearch calcium channel complexsearch extracellular regionsearch neuron projectionsearch carbohydrate metabolic processsearch response to amphetaminesearch regulation of high voltage-gated calcium channel activitysearch signal transductionsearch inositol phosphate metabolic processsearch innate immune responsesearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contractionsearch glycogen catabolic processsearch regulation of cytokinesissearch synaptic transmissionsearch small molecule metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of protein dephosphorylationsearch positive regulation of protein autophosphorylationsearch nitric oxide metabolic processsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch response to calcium ionsearch membrane organizationsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch activation of adenylate cyclase activitysearch Fc-epsilon receptor signaling pathwaysearch rhodopsin mediated signaling pathwaysearch regulation of nitric-oxide synthase activitysearch muscle contractionsearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of phosphoprotein phosphatase activitysearch regulation of rhodopsin mediated signaling pathwaysearch blood coagulationsearch fibroblast growth factor receptor signaling pathwaysearch regulation of heart ratesearch substantia nigra developmentsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of peptidyl-threonine phosphorylationsearch platelet activationsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch glucose metabolic processsearch negative regulation of peptidyl-threonine phosphorylationsearch phototransduction, visible lightsearch G-protein coupled receptor signaling pathwaysearch positive regulation of protein serine/threonine kinase activitysearch activation of phospholipase C activitysearch positive regulation of nitric-oxide synthase activitysearch epidermal growth factor receptor signaling pathwaysearch calcium-mediated signalingsearch response to corticosteronesearch detection of calcium ionsearch platelet degranulationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch