PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS
The structure was published by Zhu, G.D., Gandhi, V.B., Gong, J., et al., Li, Q., Rosenberg, S.H., and Giranda, V.L., in 2007 in a paper entitled "Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.
The experimental data on which the structure is based was not deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, and CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: