2uzv Summary

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PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS

The structure was published by Zhu, G.D., Gandhi, V.B., Gong, J., et al., Li, Q., Rosenberg, S.H., and Giranda, V.L., in 2007 in a paper entitled "Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, and CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
2 CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, Q3SX13 (6-25) (IPKA_BOVIN)search Bos taurussearch < 90% 20 100%
A CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT P00517 (16-351) (KAPCA_BOVIN)search Bos taurussearch 96% 336 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q3SX13 (6 - 25) CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, BOS TAURUS
P00517 (16 - 351) CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
2 cAMP-dependent protein kinase inhibitorsearch
A (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
2 (Q3SX13) negative regulation of protein kinase activitysearch cAMP-dependent protein kinase inhibitor activitysearch
A (P00517) peptidyl-serine phosphorylationsearch positive regulation of cell cycle arrestsearch phosphorylationsearch cellular response to glucose stimulussearch protein phosphorylationsearch protein autophosphorylationsearch positive regulation of protein export from nucleussearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch neural tube closuresearch regulation of proteasomal protein catabolic processsearch regulation of osteoblast differentiationsearch regulation of tight junction assemblysearch mesoderm formationsearch regulation of protein processingsearch peptidyl-threonine phosphorylationsearch cellular response to parathyroid hormone stimulussearch regulation of synaptic transmissionsearch sperm capacitationsearch protein kinase bindingsearch cAMP-dependent protein kinase activitysearch kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch transferase activitysearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch protein kinase A regulatory subunit bindingsearch cytoplasmsearch centrosomesearch sperm midpiecesearch plasma membranesearch ciliary basesearch AMP-activated protein kinase complexsearch neuromuscular junctionsearch nucleussearch mitochondrionsearch membranesearch extracellular vesicular exosomesearch

Chain InterPro annotation
2 cAMP-dependent protein kinase inhibitorsearch
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch