2uzu Summary

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PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS

The structure was published by Zhu, G.D., Gandhi, V.B., Gong, J., et al., Li, Q., Rosenberg, S.H., and Giranda, V.L., in 2007 in a paper entitled "Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT and CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT P00517 (16-351) (KAPCA_BOVIN)search Bos taurussearch 96% 336 100%
I CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA Q3SX13 (6-25) (IPKA_BOVIN)search Bos taurussearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (16 - 351) CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT Bos taurus
Q3SX13 (6 - 25) CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
E (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
E (P00517) regulation of tight junction assemblysearch mesoderm formationsearch phosphorylationsearch positive regulation of cell cycle arrestsearch peptidyl-serine phosphorylationsearch neural tube closuresearch regulation of synaptic transmissionsearch protein phosphorylationsearch regulation of proteasomal protein catabolic processsearch peptidyl-threonine phosphorylationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch regulation of protein processingsearch sperm capacitationsearch positive regulation of protein export from nucleussearch regulation of osteoblast differentiationsearch cellular response to parathyroid hormone stimulussearch protein autophosphorylationsearch cellular response to glucose stimulussearch neuromuscular junctionsearch plasma membranesearch centrosomesearch nucleussearch membranesearch cytoplasmsearch mitochondrionsearch sperm midpiecesearch extracellular vesicular exosomesearch AMP-activated protein kinase complexsearch ciliary basesearch protein kinase bindingsearch cAMP-dependent protein kinase activitysearch ubiquitin protein ligase bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch nucleotide bindingsearch protein kinase activitysearch kinase activitysearch protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase A regulatory subunit bindingsearch transferase activitysearch protein serine/threonine/tyrosine kinase activitysearch
I (Q3SX13) negative regulation of protein kinase activitysearch cAMP-dependent protein kinase inhibitor activitysearch

Chain InterPro annotation
E Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch