› 2uzp

X-ray diffraction
2Å resolution

Crystal structure of the C2 domain of human protein kinase C gamma.

Released:
DOI: 10.2210/pdb2uzp/pdb
PDB entry 2uzp coloured by chain, front view.
PDB entry 2uzp coloured by chain, side view.
PDB entry 2uzp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Amos A, Johansson C, Sobott F, Savitsky P, Berridge G, Fedorov O, Umeano C, Gorrec F, Bunkoczi G, Debreczeni J, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Sundstrom M, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138535 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C gamma type Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 144 amino acids
Theoretical weight: 16.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05129 (Residues: 154-295; Coverage: 20%)
Gene names: PKCG, PRKCG
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

5 bound ligands:
Ligand PLP 3 x PLP
Ligand CO 3 x CO
Ligand CA 9 x CA
Ligand SO4 20 x SO4
Ligand EDO 8 x EDO
1 modified residue:
Ligand DSN 3 x DSN

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 138.503Å b: 138.503Å c: 68.358Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.205
Expression system: Escherichia coli BL21(DE3)

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