2uzl Summary

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CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR

The structure was published by Richardson, C.M., Nunns, C.L., Williamson, D.S., et al., Simmonite, H., Surgenor, A.E., and Torrance, C.J., in 2007 in a paper entitled "Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 99%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch histone kinase activitysearch nucleotide bindingsearch cyclin bindingsearch metal ion bindingsearch transferase activitysearch protein phosphorylationsearch cell divisionsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch regulation of gene silencingsearch cellular response to DNA damage stimulussearch DNA replicationsearch mitotic cell cyclesearch blood coagulationsearch positive regulation of cell proliferationsearch Ras protein signal transductionsearch DNA repairsearch G1/S transition of mitotic cell cyclesearch mitotic nuclear divisionsearch histone phosphorylationsearch cellular response to nitric oxidesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch meiotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch centrosome duplicationsearch potassium ion transportsearch cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch nucleoplasmsearch X chromosomesearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch transcription factor complexsearch endosomesearch centrosomesearch chromosome, telomeric regionsearch microtubule organizing centersearch Cajal bodysearch cytoplasmsearch condensed chromosomesearch Y chromosomesearch cytoskeletonsearch
B, D (P20248) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch