2uze Summary

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CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR

The structure was published by Richardson, C.M., Nunns, C.L., Williamson, D.S., et al., Simmonite, H., Surgenor, A.E., and Torrance, C.J., in 2007 in a paper entitled "Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch transferase activitysearch protein bindingsearch kinase activitysearch metal ion bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch G1/S transition of mitotic cell cyclesearch regulation of gene silencingsearch DNA replicationsearch cellular response to nitric oxidesearch Ras protein signal transductionsearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch cell divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch G2/M transition of mitotic cell cyclesearch centrosome duplicationsearch DNA repairsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic G2 phasesearch cell cyclesearch meiotic nuclear divisionsearch mitotic nuclear divisionsearch histone phosphorylationsearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of cell proliferationsearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch potassium ion transportsearch nucleoplasmsearch cytosolsearch cytoplasmsearch X chromosomesearch endosomesearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch nucleussearch transcription factor complexsearch microtubule organizing centersearch Y chromosomesearch cytoskeletonsearch condensed chromosomesearch centrosomesearch chromosome, telomeric regionsearch
B, D (P20248) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch