2uze Summary

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CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR

The structure was published by Richardson, C.M., Nunns, C.L., Williamson, D.S., et al., Simmonite, H., Surgenor, A.E., and Torrance, C.J., in 2007 in a paper entitled "Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch DNA repairsearch centrosome duplicationsearch G1/S transition of mitotic cell cyclesearch DNA replicationsearch regulation of gene silencingsearch cell divisionsearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch cellular response to nitric oxidesearch Ras protein signal transductionsearch potassium ion transportsearch G2/M transition of mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to DNA damage stimulussearch meiotic cell cyclesearch meiotic nuclear divisionsearch positive regulation of cell proliferationsearch blood coagulationsearch cell cyclesearch histone phosphorylationsearch ATP bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch kinase activitysearch metal ion bindingsearch protein kinase activitysearch cyclin bindingsearch nucleotide bindingsearch histone kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch nucleoplasmsearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch Cajal bodysearch X chromosomesearch transcription factor complexsearch cytoskeletonsearch nucleussearch microtubule organizing centersearch Y chromosomesearch chromosome, telomeric regionsearch endosomesearch centrosomesearch condensed chromosomesearch
B, D (P20248) regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch