› 2uzc

X-ray diffraction
1.5Å resolution

Structure of human PDLIM5 in complex with the C-terminal peptide of human alpha-actinin-1

Released:
DOI: 10.2210/pdb2uzc/pdb
PDB entry 2uzc coloured by chain, front view.
PDB entry 2uzc coloured by chain, side view.
PDB entry 2uzc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz JR, Doyle DA
Protein Sci 19 731-41 (2010)
PMID: 20120020

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188530 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PDZ and LIM domain protein 5 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 88 amino acids
Theoretical weight: 9.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96HC4 (Residues: 1-85; Coverage: 14%)
Gene names: ENH, L9, PDLIM5
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
Ligand CL 6 x CL
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 61.25Å b: 36.474Å c: 88.706Å
α: 90° β: 99.15° γ: 90°
R-values:
R R work R free
0.166 0.163 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
4 more

4 mentions without citation

Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins et al. (2010)
3 more