› 2uxh

X-ray diffraction
2.4Å resolution

TtgR in complex with Quercetin

Released:
DOI: 10.2210/pdb2uxh/pdb
PDB entry 2uxh coloured by chain, front view.
PDB entry 2uxh coloured by chain, side view.
PDB entry 2uxh coloured by chain, top view.
Source organism: Pseudomonas putida
Primary publication:
Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials.
Alguel Y, Meng C, Terán W, Krell T, Ramos JL, Gallegos MT, Zhang X
J Mol Biol 369 829-40 (2007)
PMID: 17466326

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator TtgR Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.89 KDa
Source organism: Pseudomonas putida
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9AIU0 (Residues: 1-210; Coverage: 100%)
Gene names: T1E_0244, ttgR
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

1 bound ligand:
Ligand QUE 2 x QUE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 46.65Å b: 231.881Å c: 44.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.237 0.295
Expression system: Escherichia coli K-12

Quick links

Citations

13 review citations

Multidrug resistance in bacteria.
Nikaido H. (2009)
12 more

9 mentions without citation

The TetR family of regulators.
Cuthbertson et al. (2013)
8 more