2uw6 Summary

pdbe.org/2uw6
spacer

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (S)-2-(4-CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE

The structure was published by Saxty, G., Woodhead, S.J., Berdini, V., et al., Downham, R., Garrett, M.D., and Carr, R.A., in 2007 in a paper entitled "Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.23 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT and CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT P00517 (2-351) (KAPCA_BOVIN)search Bos taurussearch 96% 351 96%
I CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA P61925 (6-25) (IPKA_HUMAN)search Homo sapienssearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (2 - 351) CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT Bos taurus
P61925 (6 - 25) CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA HOMO SAPIENS

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00517) protein kinase activitysearch protein serine/threonine kinase activitysearch protein kinase bindingsearch kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch ATP bindingsearch cAMP-dependent protein kinase activitysearch protein bindingsearch nucleotide bindingsearch protein kinase A regulatory subunit bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch phosphorylationsearch regulation of osteoblast differentiationsearch neural tube closuresearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch sperm capacitationsearch positive regulation of protein export from nucleussearch cellular response to parathyroid hormone stimulussearch positive regulation of cell cycle arrestsearch peptidyl-serine phosphorylationsearch cellular response to glucose stimulussearch regulation of synaptic transmissionsearch protein autophosphorylationsearch regulation of protein processingsearch regulation of tight junction assemblysearch regulation of proteasomal protein catabolic processsearch peptidyl-threonine phosphorylationsearch mesoderm formationsearch membranesearch cytoplasmsearch plasma membranesearch ciliary basesearch neuromuscular junctionsearch nucleussearch mitochondrionsearch AMP-activated protein kinase complexsearch extracellular vesicular exosomesearch sperm midpiecesearch centrosomesearch
I (P61925) cAMP-dependent protein kinase inhibitor activitysearch negative regulation of protein kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch