2tun Summary

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CONFORMATIONAL CHANGES IN THE (ALA-84-VAL) MUTANT OF TUMOR NECROSIS FACTOR

A publication describing this structure is not available. The depositing authors are Saludjian, P.search; Prange, T.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of TUMOR NECROSIS FACTOR-ALPHA.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
B TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
C TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
D TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
E TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
F TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) TUMOR NECROSIS FACTOR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F TNF-likesearch Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F (P01375) immune responsesearch tumor necrosis factor receptor bindingsearch membranesearch

Chain InterPro annotation
A, B, C, D, E, F Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch