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TYROSINE PHENOL-LYASE FROM CITROBACTER INTERMEDIUS COMPLEX WITH 3-(4'-HYDROXYPHENYL)PROPIONIC ACID, PYRIDOXAL-5'-PHOSPHATE AND CS+ ION

Source organism: Citrobacter freundii
Biochemical function: tyrosine phenol-lyase activity
Biological process: aromatic amino acid metabolic process
Cellular component: not assigned

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EC 4.1.99.2: Tyrosine phenol-lyase

Reaction catalysed:
(1a) L-tyrosine = phenol + 2-aminoprop-2-enoate
Systematic name:
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Alternative Name(s):
  • Beta-tyrosinase
  • L-tyrosine phenol-lyase (deaminating)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01212
Domain description: Beta-eliminating lyase
Occurring in:
  1. Tyrosine phenol-lyase
The deposited structure of PDB entry 2tpl contains 2 copies of Pfam domain PF01212 (Beta-eliminating lyase) in Tyrosine phenol-lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013441
Domain description: Tyrosine phenol-lyase
Occurring in:
  1. Tyrosine phenol-lyase
IPR018176
Domain description: Tryptophanase, conserved site
Occurring in:
  1. Tyrosine phenol-lyase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Tyrosine phenol-lyase
IPR001597
Domain description: Aromatic amino acid beta-eliminating lyase/threonine aldolase
Occurring in:
  1. Tyrosine phenol-lyase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Tyrosine phenol-lyase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Tyrosine phenol-lyase
IPR011166
Domain description: Beta-eliminating lyase family
Occurring in:
  1. Tyrosine phenol-lyase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Tyrosine phenol-lyase
The deposited structure of PDB entry 2tpl contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Tyrosine phenol-lyase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Tyrosine phenol-lyase
The deposited structure of PDB entry 2tpl contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Tyrosine phenol-lyase. Showing 1 copy in chain A.
SCOP SCOP annotation
53397
Class: Alpha and beta proteins (a/b)
Fold: PLP-dependent transferase-like
Superfamily: PLP-dependent transferases
Occurring in:
  1. Tyrosine phenol-lyase
The deposited structure of PDB entry 2tpl contains 2 copies of SCOP domain 53397 (Beta-eliminating lyases) in Tyrosine phenol-lyase. Showing 1 copy in chain A.

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