2tmd Summary

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CORRELATION OF X-RAY DEDUCED AND EXPERIMENTAL AMINO ACID SEQUENCES OF TRIMETHYLAMINE DEHYDROGENASE

The structure was published by Barber, M.J., Neame, P.J., Lim, L.W., White, S., and Matthews, F.S., in 1992 in a paper entitled "Correlation of x-ray deduced and experimental amino acid sequences of trimethylamine dehydrogenase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of TRIMETHYLAMINE DEHYDROGENASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRIMETHYLAMINE DEHYDROGENASE P16099 (2-730) (DHTM_METME)search Methylophilus methylotrophussearch 100% 729 100%
B TRIMETHYLAMINE DEHYDROGENASE P16099 (2-730) (DHTM_METME)search Methylophilus methylotrophussearch 100% 729 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16099 (2 - 730) TRIMETHYLAMINE DEHYDROGENASE Methylophilus methylotrophus W3A1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P16099) FMN-linked oxidoreductasessearch, C-terminal domain of adrenodoxin reductase-likesearch, N-terminal domain of adrenodoxin reductase-likesearch Aldolase class Isearch, NAD(P)-binding Rossmann-like Domainsearch, FAD/NAD(P)-binding domainsearch PF00724: NADH:flavin oxidoreductase / NADH oxidase familysearch, PF07992: Pyridine nucleotide-disulphide oxidoreductasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P16099) 4 iron, 4 sulfur cluster bindingsearch FMN bindingsearch catalytic activitysearch oxidoreductase activitysearch metal ion bindingsearch iron-sulfur cluster bindingsearch trimethylamine dehydrogenase activitysearch oxidation-reduction processsearch

Chain InterPro annotation
A, B NADH:flavin oxidoreductase/NADH oxidase, N-terminalsearch FAD-dependent pyridine nucleotide-disulphide oxidoreductasesearch Aldolase-type TIM barrelsearch NAD(P)-binding domainsearch Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domainsearch