2tci Summary

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PDB entry 2tci (supersedes 1tci)

X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL

The structure was published by Whittingham, J.L., Chaudhuri, S., Dodson, E.J., Moody, P.C., and Dodson, G.G., in 1995 in a paper entitled "X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely THIOCYANATE INSULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A THIOCYANATE INSULIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
C THIOCYANATE INSULIN P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
B THIOCYANATE INSULIN P01315 (25-54) (INS_PIG)search Sus scrofasearch < 90% 30 100%
D THIOCYANATE INSULIN P01315 (25-54) (INS_PIG)search Sus scrofasearch < 90% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01315 (88 - 108) THIOCYANATE INSULIN Sus scrofa

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C Insulin-likesearch Insulin/IGF/Relaxin familysearch
B, D Insulin-likesearch Insulin/IGF/Relaxin familysearch

Chain ID Cellular component (GO) Molecular function (GO)
A, C (P01315) extracellular regionsearch hormone activitysearch
B, D (P01315) extracellular regionsearch hormone activitysearch

Chain InterPro annotation
A, C Insulin-likesearch Insulin, conserved sitesearch
B, D Insulinsearch Insulin-likesearch