2src Summary

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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP

The structure was published by Xu, W., Doshi, A., Lei, M., Eck, M.J., and Harrison, S.C., in 1999 in a paper entitled "Crystal structures of c-Src reveal features of its autoinhibitory mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of TYROSINE-PROTEIN KINASE SRC. This molecule has the UniProt identifier P12931 (SRC_HUMAN)search. The sample contained 452 residues which is < 90% of the natural sequence. Out of 452 residues 449 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE SRC P12931 (86-536) (SRC_HUMAN)search Homo sapienssearch 100% 452 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (86 - 536) TYROSINE-PROTEIN KINASE SRC Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12931) SH3-domainsearch, SH2 domainsearch, Protein kinases, catalytic subunitsearch SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00017: SH2 domainsearch, PF00018: SH3 domainsearch, PF07714: Protein tyrosine kinasesearch
Chain InterPro annotation
A Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch SH3 domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch