2seb Summary

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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II

The structure was published by Dessen, A., Lawrence, C.M., Cupo, S., Zaller, D.M., and Wiley, D.C., in 1997 in a paper entitled "X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This entry contains 9 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P01903 (26-206) (DRA_HUMAN)search Homo sapienssearch < 90% 181 99%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN Not available
Homo sapienssearch Not available 192 92%
D ENTEROTOXIN TYPE B P01552 (28-266) (ETXB_STAAU)search Staphylococcus aureussearch 98% 239 90%
E PEPTIDE FROM COLLAGEN II P02458 (1238-1247) (CO2A1_HUMAN)search Homo sapienssearch < 90% 12 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 206) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN Homo sapiens
P01552 (28 - 266) ENTEROTOXIN TYPE B Staphylococcus aureus
P02458 (1238 - 1247) PEPTIDE FROM COLLAGEN II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B
D (P01552) Superantigen toxins, N-terminal domainsearch, Superantigen toxins, C-terminal domainsearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search, Ubiquitin-like (UB roll)search PF01123: Staphylococcal/Streptococcal toxin, OB-fold domainsearch, PF02876: Staphylococcal/Streptococcal toxin, beta-grasp domainsearch
E

Chain ID Cellular component (GO) Biological process (GO)
A (P01903) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch
B () MHC class II protein complexsearch membranesearch immune responsesearch antigen processing and presentationsearch
D (P01552) extracellular regionsearch pathogenesissearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
D Staphylococcal/Streptococcal toxin, beta-grasp domainsearch Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved sitesearch Staphylococcal/Streptococcal toxin, OB-foldsearch Staphylococcal/streptococcal toxin, bacterialsearch Enterotoxinsearch Superantigen, staphylococcal/streptococcal toxin, bacterialsearch Superantigen toxin, C-terminalsearch
E