2rol Summary

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Structural Basis of PxxDY motif recognition in SH3 binding

The structure was published by Aitio, O., Hellman, M., Kesti, T., et al., Tossavainen, H., Saksela, K., and Permi, P., in 2008 in a paper entitled "Structural basis of PxxDY motif recognition in SH3 binding" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal growth factor receptor kinase substrate 8-like protein 1 and 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor kinase substrate 8-like protein 1 Q8TE68 (478-537) (ES8L1_HUMAN)search Homo sapienssearch < 90% 64 100%
B 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain P07766 (181-192) (CD3E_HUMAN)search Homo sapienssearch < 90% 12 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8TE68 (478 - 537) Epidermal growth factor receptor kinase substrate 8-like protein 1 Homo sapiens
P07766 (181 - 192) 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain

Chain Structural classification (CATH) Sequence family (Pfam)
A SH3 Domainssearch SH3 domainsearch
B Immunoreceptor tyrosine-based activation motifsearch
Chain InterPro annotation
A SH3 domainsearch
B