› 2rmb

X-ray diffraction
2.1Å resolution

Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A

Released:
DOI: 10.2210/pdb2rmb/pdb
PDB entry 2rmb coloured by chain, front view.
PDB entry 2rmb coloured by chain, side view.
PDB entry 2rmb coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A.
Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT
Structure 2 33-44 (1994)
PMID: 8075981

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158801 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chains: A, C, E, G, I, K, M, O, Q, S
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chains: B, D, F, H, J, L, N, P, R, T
Molecule details ›
Chains: B, D, F, H, J, L, N, P, R, T
Length: 11 amino acids
Theoretical weight: 1.23 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 10 x DAL
Ligand MLE 40 x MLE
Ligand MVA 10 x MVA
Ligand DMT 10 x DMT
Ligand ABA 10 x ABA
Ligand SAR 10 x SAR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 72.6Å b: 160.6Å c: 95.3Å
α: 90° β: 90.9° γ: 90°
R-values:
R R work R free
0.184 0.184 not available
Expression system: Not provided

Quick links

Citations

7 review citations

Peptidylproline cis/trans isomerases.
Galat et al. (1995)
6 more