2rk6 Summary

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Structure of E163K DJ-1

The structure was published by Lakshminarasimhan, M., Maldonado, M.T., Zhou, W., Fink, A.L., and Wilson, M.A., in 2008 in a paper entitled "Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.15 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 192 residues which is 100% of the natural sequence. Out of 192 residues 186 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 192 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q99497) membrane depolarizationsearch negative regulation of protein phosphorylationsearch negative regulation of cell deathsearch negative regulation of hydrogen peroxide-induced neuron deathsearch negative regulation of gene expressionsearch negative regulation of hydrogen peroxide-induced cell deathsearch positive regulation of tyrosine 3-monooxygenase activitysearch regulation of neuron apoptotic processsearch cellular response to oxidative stresssearch oxidation-reduction processsearch positive regulation of L-dopa decarboxylase activitysearch positive regulation of pyrroline-5-carboxylate reductase activitysearch positive regulation of L-dopa biosynthetic processsearch positive regulation of oxidative phosphorylation uncoupler activitysearch negative regulation of protein kinase activitysearch positive regulation of protein homodimerization activitysearch negative regulation of protein bindingsearch negative regulation of apoptotic processsearch negative regulation of protein sumoylationsearch positive regulation of superoxide dismutase activitysearch synaptic transmission, dopaminergicsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch cellular response to hydrogen peroxidesearch negative regulation of neuron apoptotic processsearch negative regulation of protein K48-linked deubiquitinationsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch hydrogen peroxide metabolic processsearch proteolysissearch negative regulation of ubiquitin-protein transferase activitysearch mitochondrion organizationsearch dopamine uptake involved in synaptic transmissionsearch positive regulation of transcription from RNA polymerase II promotersearch response to stresssearch negative regulation of death-inducing signaling complex assemblysearch cellular response to glyoxalsearch regulation of inflammatory responsesearch negative regulation of neuron deathsearch protein stabilizationsearch methylglyoxal catabolic process to D-lactatesearch lactate biosynthetic processsearch cellular response to reactive oxygen speciessearch cell deathsearch negative regulation of protein ubiquitinationsearch negative regulation of ubiquitin-specific protease activitysearch regulation of mitochondrial membrane potentialsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch single fertilizationsearch positive regulation of interleukin-8 productionsearch glycolate biosynthetic processsearch autophagysearch membrane hyperpolarizationsearch positive regulation of androgen receptor activitysearch positive regulation of dopamine biosynthetic processsearch adult locomotory behaviorsearch regulation of TRAIL receptor biosynthetic processsearch inflammatory responsesearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of protein acetylationsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch positive regulation of protein localization to nucleussearch negative regulation of oxidative stress-induced cell deathsearch regulation of androgen receptor signaling pathwaysearch glyoxal catabolic processsearch negative regulation of protein export from nucleussearch response to hydrogen peroxidesearch extracellular vesicular exosomesearch mitochondrionsearch cytosolsearch membrane raftsearch plasma membranesearch nucleussearch cytoplasmsearch mitochondrial respiratory chain complex Isearch chromatinsearch PML bodysearch membranesearch protein bindingsearch double-stranded DNA bindingsearch small protein activating enzyme bindingsearch tyrosine 3-monooxygenase activator activitysearch repressing transcription factor bindingsearch hydrolase activitysearch identical protein bindingsearch small protein conjugating enzyme bindingsearch protein homodimerization activitysearch cuprous ion bindingsearch enzyme bindingsearch peroxiredoxin activitysearch peroxidase activitysearch cupric ion bindingsearch core promoter bindingsearch ubiquitin-specific protease bindingsearch scaffold protein bindingsearch receptor bindingsearch transcription coactivator activitysearch peptidase activitysearch single-stranded DNA bindingsearch transcription factor bindingsearch glyoxalase (glycolic acid-forming) activitysearch glyoxalase III activitysearch mRNA bindingsearch superoxide dismutase copper chaperone activitysearch cytokine bindingsearch L-dopa decarboxylase activator activitysearch oxidoreductase activity, acting on peroxide as acceptorsearch RNA bindingsearch androgen receptor bindingsearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch