2rk4 Summary


Structure of M26I DJ-1

The structure was published by Lakshminarasimhan, M., Maldonado, M.T., Zhou, W., Fink, A.L., and Wilson, M.A., in 2008 in a paper entitled "Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.15 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 197 residues which is 100% of the natural sequence. Out of 197 residues 186 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 197 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q99497) extracellular vesicular exosomesearch cytoplasmsearch mitochondrionsearch mitochondrial respiratory chain complex Isearch nucleussearch cytosolsearch axonsearch chromatinsearch PML bodysearch membranesearch plasma membranesearch membrane raftsearch protein bindingsearch scaffold protein bindingsearch repressing transcription factor bindingsearch small protein activating enzyme bindingsearch enzyme bindingsearch ubiquitin-specific protease bindingsearch small protein conjugating enzyme bindingsearch single-stranded DNA bindingsearch peptidase activitysearch androgen receptor bindingsearch peroxidase activitysearch cuprous ion bindingsearch protein homodimerization activitysearch glyoxalase (glycolic acid-forming) activitysearch double-stranded DNA bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch receptor bindingsearch RNA bindingsearch core promoter bindingsearch cytokine bindingsearch identical protein bindingsearch transcription coactivator activitysearch glyoxalase III activitysearch mRNA bindingsearch superoxide dismutase copper chaperone activitysearch hydrolase activitysearch cupric ion bindingsearch tyrosine 3-monooxygenase activator activitysearch peroxiredoxin activitysearch L-dopa decarboxylase activator activitysearch transcription factor bindingsearch response to hydrogen peroxidesearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch negative regulation of protein bindingsearch negative regulation of neuron deathsearch Ras protein signal transductionsearch proteolysissearch regulation of TRAIL receptor biosynthetic processsearch positive regulation of L-dopa biosynthetic processsearch positive regulation of protein kinase B signalingsearch mitochondrion organizationsearch negative regulation of protein acetylationsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of extrinsic apoptotic signaling pathwaysearch positive regulation of protein homodimerization activitysearch regulation of inflammatory responsesearch negative regulation of protein ubiquitinationsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch hydrogen peroxide metabolic processsearch positive regulation of androgen receptor activitysearch negative regulation of apoptotic processsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of cell deathsearch cellular response to oxidative stresssearch positive regulation of transcription regulatory region DNA bindingsearch lactate biosynthetic processsearch membrane depolarizationsearch negative regulation of gene expressionsearch negative regulation of oxidative stress-induced cell deathsearch regulation of fibril organizationsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch protein stabilizationsearch positive regulation of gene expressionsearch inflammatory responsesearch negative regulation of ubiquitin-protein transferase activitysearch synaptic transmission, dopaminergicsearch membrane hyperpolarizationsearch negative regulation of hydrogen peroxide-induced neuron deathsearch glyoxal catabolic processsearch positive regulation of tyrosine 3-monooxygenase activitysearch cellular response to hydrogen peroxidesearch single fertilizationsearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of protein localization to nucleussearch glycolate biosynthetic processsearch positive regulation of L-dopa decarboxylase activitysearch negative regulation of protein K48-linked deubiquitinationsearch regulation of neuron apoptotic processsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch regulation of androgen receptor signaling pathwaysearch negative regulation of death-inducing signaling complex assemblysearch activation of protein kinase B activitysearch negative regulation of hydrogen peroxide-induced cell deathsearch negative regulation of protein sumoylationsearch positive regulation of dopamine biosynthetic processsearch cellular response to glyoxalsearch negative regulation of protein export from nucleussearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch negative regulation of protein kinase activitysearch adult locomotory behaviorsearch positive regulation of oxidative phosphorylation uncoupler activitysearch positive regulation of interleukin-8 productionsearch regulation of mitochondrial membrane potentialsearch negative regulation of proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to reactive oxygen speciessearch positive regulation of pyrroline-5-carboxylate reductase activitysearch autophagysearch negative regulation of protein phosphorylationsearch negative regulation of ubiquitin-specific protease activitysearch oxidation-reduction processsearch negative regulation of neuron apoptotic processsearch positive regulation of superoxide dismutase activitysearch methylglyoxal catabolic process to D-lactatesearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch