› 2rgi

X-ray diffraction
1.6Å resolution

Crystal structure of Ca2+-free S100A2 at 1.6 A resolution

Released:
DOI: 10.2210/pdb2rgi/pdb
PDB entry 2rgi coloured by chain, front view.
PDB entry 2rgi coloured by chain, side view.
PDB entry 2rgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Ca2+ -free S100A2 at 1.6-A resolution.
Koch M, Diez J, Fritz G
J Mol Biol 378 933-42 (2008)
PMID: 18394645

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151335 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29034 (Residues: 1-98; Coverage: 100%)
Gene names: S100A2, S100L
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand NA 3 x NA
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 43.516Å b: 57.82Å c: 59.794Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.
Fritz et al. (2010)
3 more

4 mentions without citation

Analysis and prediction of calcium-binding pockets from apo-protein structures exhibiting calcium-induced localized conformational changes.
Wang et al. (2010)
3 more