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Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

X-ray diffraction
2.9Å resolution
PDB entry 2rfe coloured by chain, front view.
PDB entry 2rfe coloured by chain, side view.
PDB entry 2rfe coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 14549.29 Å2
Buried surface area: 1827.15 Å2
Dissociation area: 913.58 Å2
Dissociation energy (ΔGdiss): 8.96 kcal/mol
Dissociation entropy (TΔSdiss): 9.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132685
Assembly 2 (preferred)
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Assembly Name: Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 14083.65 Å2
Buried surface area: 1784.23 Å2
Dissociation area: 892.11 Å2
Dissociation energy (ΔGdiss): 9.07 kcal/mol
Dissociation entropy (TΔSdiss): 9.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132685
Assembly 3
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Assembly Name: Epidermal growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 12789.24 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132671
Assembly 4
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Assembly Name: Epidermal growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 13581.44 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132671

Macromolecules

Epidermal growth factor receptor
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 702-1022; Coverage: 27%)
Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Epidermal growth factor receptor in PDB entry 2rfe, assembly 2, front view.
Epidermal growth factor receptor in PDB entry 2rfe, assembly 2, side view.
Epidermal growth factor receptor in PDB entry 2rfe, assembly 2, top view.
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ERBB receptor feedback inhibitor 1
Chains: E, F
Length: 40 amino acids
Theoretical weight: 4.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UJM3 (Residues: 325-364; Coverage: 9%)
Gene names: ERRFI1, MIG6
Pfam: EGFR receptor inhibitor Mig-6
ERBB receptor feedback inhibitor 1 in PDB entry 2rfe, assembly 2, front view.
ERBB receptor feedback inhibitor 1 in PDB entry 2rfe, assembly 2, side view.
ERBB receptor feedback inhibitor 1 in PDB entry 2rfe, assembly 2, top view.
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