2rfd Summary

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Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

The structure was published by Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., and Kuriyan, J., in 2007 in a paper entitled "Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (702-1022) (EGFR_HUMAN)search Homo sapienssearch < 90% 324 88%
B Epidermal growth factor receptor P00533 (702-1022) (EGFR_HUMAN)search Homo sapienssearch < 90% 324 88%
C ERBB receptor feedback inhibitor 1 Q9UJM3 (340-364) (ERRFI_HUMAN)search Homo sapienssearch < 90% 25 64%
D ERBB receptor feedback inhibitor 1 Q9UJM3 (340-364) (ERRFI_HUMAN)search Homo sapienssearch < 90% 25 64%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00533 (702 - 1022) Epidermal growth factor receptor Homo sapiens
Q9UJM3 (340 - 364) ERBB receptor feedback inhibitor 1

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
C, D EGFR receptor inhibitor Mig-6search

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00533) protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
C, D EGFR receptor inhibitor Mig-6search