2rf9 Summary

pdbe.org/2rf9
spacer

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

The structure was published by Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., and Kuriyan, J., in 2007 in a paper entitled "Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal growth factor receptor and ERBB receptor feedback inhibitor 1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (696-1022) (EGFR_HUMAN)search Homo sapienssearch < 90% 330 84%
B Epidermal growth factor receptor P00533 (696-1022) (EGFR_HUMAN)search Homo sapienssearch < 90% 330 84%
C ERBB receptor feedback inhibitor 1 Q9UJM3 (315-374) (ERRFI_HUMAN)search Homo sapienssearch < 90% 65 41%
D ERBB receptor feedback inhibitor 1 Q9UJM3 (315-374) (ERRFI_HUMAN)search Homo sapienssearch < 90% 65 41%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00533 (696 - 1022) Epidermal growth factor receptor Homo sapiens
Q9UJM3 (315 - 374) ERBB receptor feedback inhibitor 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
C, D EGFR receptor inhibitor Mig-6search

Chain ID Biological process (GO) Molecular function (GO)
A, B (P00533) protein phosphorylationsearch protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
C, D EGFR receptor inhibitor Mig-6search