2rf0 Summary

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Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

A publication describing this structure is not available. The depositing authors are Ugochukwu, E.search; Eswaran, J.search; Elkins, J.search; Keates, T.search; Pike, A.C.W.search; Berridge, G.search; Savitsky, P.search; Sundstrom, M.search; Arrowsmith, C.H.search; Weigelt, J.search; Edwards, A.M.search; von Delft, F.search; Knapp, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase kinase kinase 10.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase kinase kinase 10 Q02779 (13-78) (M3K10_HUMAN)search Homo sapienssearch < 90% 89 69%
B Mitogen-activated protein kinase kinase kinase 10 Q02779 (13-78) (M3K10_HUMAN)search Homo sapienssearch < 90% 89 69%
C Mitogen-activated protein kinase kinase kinase 10 Q02779 (13-78) (M3K10_HUMAN)search Homo sapienssearch < 90% 89 69%
D Mitogen-activated protein kinase kinase kinase 10 Q02779 (13-78) (M3K10_HUMAN)search Homo sapienssearch < 90% 89 69%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02779 (13 - 78) Mitogen-activated protein kinase kinase kinase 10 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D SH3 Domainssearch Variant SH3 domainsearch

Chain ID Molecular function (GO)
A, B, C, D (Q02779) MAP kinase kinase kinase activitysearch

Chain InterPro annotation
A, B, C, D SH3 domainsearch Mitogen-activated protein (MAP) kinase kinase kinase 10search