2rey Summary


Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)

A publication describing this structure is not available. The depositing authors are Papagrigoriou, E.search; Gileadi, C.search; Elkins, J.search; Cooper, C.search; Ugochukwu, E.search; Turnbull, A.search; Pike, A.C.W.search; Gileadi, O.search; von Delft, F.search; Sundstrom, M.search; Arrowsmith, C.H.search; Weigelt, J.search; Edwards, A.M.search; Doyle, D.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Segment polarity protein dishevelled homolog DVL-2. This molecule has the UniProt identifier O14641 (DVL2_HUMAN)search. The sample contained 100 residues which is < 90% of the natural sequence. Out of 100 residues 89 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Segment polarity protein dishevelled homolog DVL-2 O14641 (261-355) (DVL2_HUMAN)search Homo sapienssearch < 90% 100 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14641 (261 - 355) Segment polarity protein dishevelled homolog DVL-2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Pdz3 Domainsearch PDZ domain (Also known as DHR or GLGF)search

Chain ID Biological process (GO)
A (O14641) Wnt signaling pathwaysearch

Chain InterPro annotation
A PDZ domainsearch Dishevelled-2search Dishevelled-related proteinsearch