2rew Summary

pdbe.org/2rew
spacer

Crystal Structure of PPARalpha ligand binding domain with BMS-631707

A publication describing this structure is not available. The depositing authors are Muckelbauer, J.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Peroxisome proliferator-activated receptor alpha. This molecule has the UniProt identifier Q07869 (PPARA_HUMAN)search. The sample contained 277 residues which is < 90% of the natural sequence. Out of 277 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor alpha Q07869 (196-468) (PPARA_HUMAN)search Homo sapienssearch < 90% 277 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07869 (196 - 468) Peroxisome proliferator-activated receptor alpha Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q07869) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, alphasearch Nuclear hormone receptor, ligand-bindingsearch