Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor
The structure was published by Gopalsamy, A., Shi, M., Boschelli, D.H., et al., Han, X., Arndt, K., and Guo, B., in 2007 in a paper entitled "Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2007.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Phosphoinositide-dependent protein kinase 1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN). The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 274 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: