2r7b Summary

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Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor

The structure was published by Gopalsamy, A., Shi, M., Boschelli, D.H., et al., Han, X., Arndt, K., and Guo, B., in 2007 in a paper entitled "Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Phosphoinositide-dependent protein kinase 1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN)search. The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphoinositide-dependent protein kinase 1 O15530 (48-359) (PDPK1_HUMAN)search Homo sapienssearch < 90% 312 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O15530 (48 - 359) Phosphoinositide-dependent protein kinase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O15530) protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch