2r6y Summary

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Estrogen receptor alpha ligand-binding domain in complex with a SERM

The structure was published by Dai, S.Y., Chalmers, M.J., Bruning, J., et al., Burris, T.P., Dodge, J.A., and Griffin, P.R., in 2008 in a paper entitled "Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (304-551) (ESR1_HUMAN)search Homo sapienssearch < 90% 248 93%
B Estrogen receptor P03372 (304-551) (ESR1_HUMAN)search Homo sapienssearch < 90% 248 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (304 - 551) Estrogen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P03372) nucleussearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch