2r64 Summary


Crystal structure of a 3-aminoindazole compound with CDK2

The structure was published by Lee, J., Choi, H., Kim, K.H., et al., Park, J.W., Baek, C.S., and Lee, S.H., in 2008 in a paper entitled "Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 279 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch ATP bindingsearch cyclin bindingsearch protein bindingsearch metal ion bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch histone kinase activitysearch transferase activitysearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch regulation of gene silencingsearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch potassium ion transportsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G2/M transition of mitotic cell cyclesearch centrosome duplicationsearch mitotic cell cyclesearch cell divisionsearch mitotic nuclear divisionsearch blood coagulationsearch DNA repairsearch phosphorylationsearch histone phosphorylationsearch Ras protein signal transductionsearch cellular response to DNA damage stimulussearch cellular response to nitric oxidesearch cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of transcription, DNA-templatedsearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch nucleoplasmsearch condensed chromosomesearch nucleussearch cytoplasmsearch cytoskeletonsearch transcription factor complexsearch Cajal bodysearch microtubule organizing centersearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch Y chromosomesearch centrosomesearch endosomesearch X chromosomesearch chromosome, telomeric regionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch