2r5t Summary

pdbe.org/2r5t
spacer

Crystal Structure of Inactive Serum and Glucocorticoid- Regulated Kinase 1 in Complex with AMP-PNP

The structure was published by Zhao, B., Lehr, R., Smallwood, A.M., et al., Head, M.S., Koretke, K.K., and Schnackenberg, C.G., in 2007 in a paper entitled "Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase Sgk1. This molecule has the UniProt identifier O00141 (SGK1_HUMAN)search. The sample contained 373 residues which is < 90% of the natural sequence. Out of 373 residues 279 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Sgk1 O00141 (60-431) (SGK1_HUMAN)search Homo sapienssearch < 90% 373 76%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O00141 (60 - 431) Serine/threonine-protein kinase Sgk1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O00141) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch