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EBI PDBe PDBeView

PDBe Entry: 2r42 view

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.4 Å, R-factor: 23.5%, Free R-factor: 27.2%, Spacegroup: P 21 21 2
Released 24/06/2008, deposition: 30/08/2007, last revision: 24/02/2009
Authors Fu, Z.search; Voynova, N.E.search; Miziorko, H.M.search; Kim, J.P.search
Primary citation Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism.
BIOCHEMISTRYsearch vol:47, pag:3715-3724 (2008) [PubMed ID 18302342 ]search
Keywords Mevalonate Kinasesearch, Farnesyl Thiodiphosphatesearch, ATP-bindingsearch, Cholesterol biosynthesissearch, Cytoplasmsearch, Lipid synthesissearch, Nucleotide-bindingsearch, Peroxisomesearch, Steroid biosynthesissearch, Sterol biosynthesissearch, Transferasesearch
EC 2.7.1.36 ExPASy BRENDA search (A)
Organism Rattus norvegicus(Norway rat) 10116search(A)
UniProt Mevalonate kinase (EC 2.7.1.36) (MK) P17256search (A)
Solvent A
Related entries 2r3v
Polymers
Id Name Type UniProt Residues Observed
A Mevalonate kinase Protein P17256 (KIME_RAT)search
 395 96%
Heterogens
Id Name Ligands
A MAGNESIUM ION MG search
A S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE FPS search
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