2r3n Summary


Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

The structure was published by Fischmann, T.O., Hruza, A., Duca, J.S., et al., Parry, D., Seghezzi, W., and Madison, V., in 2008 in a paper entitled "Structure-guided discovery of cyclin-dependent kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein bindingsearch cyclin bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch histone kinase activitysearch metal ion bindingsearch blood coagulationsearch meiotic nuclear divisionsearch Ras protein signal transductionsearch potassium ion transportsearch positive regulation of cell proliferationsearch G2/M transition of mitotic cell cyclesearch mitotic nuclear divisionsearch phosphorylationsearch protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch cellular response to nitric oxidesearch positive regulation of DNA-dependent DNA replication initiationsearch DNA replicationsearch mitotic cell cyclesearch centrosome duplicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell cyclesearch DNA repairsearch regulation of gene silencingsearch mitotic G1 DNA damage checkpointsearch cell divisionsearch cellular response to DNA damage stimulussearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch G1/S transition of mitotic cell cyclesearch histone phosphorylationsearch cytoplasmsearch nucleoplasmsearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch X chromosomesearch endosomesearch cytosolsearch condensed chromosomesearch cytoskeletonsearch microtubule organizing centersearch chromosome, telomeric regionsearch centrosomesearch Y chromosomesearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch