2r3m Summary


Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

The structure was published by Fischmann, T.O., Hruza, A., Duca, J.S., et al., Parry, D., Seghezzi, W., and Madison, V., in 2008 in a paper entitled "Structure-guided discovery of cyclin-dependent kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 280 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch regulation of gene silencingsearch mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch positive regulation of cell proliferationsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch cell cyclesearch Ras protein signal transductionsearch centrosome duplicationsearch cellular response to DNA damage stimulussearch DNA repairsearch phosphorylationsearch meiotic nuclear divisionsearch potassium ion transportsearch cellular response to nitric oxidesearch cell divisionsearch histone phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G2 phasesearch mitotic G1 DNA damage checkpointsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch ATP bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch cyclin bindingsearch metal ion bindingsearch transferase activitysearch histone kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleoplasmsearch endosomesearch nucleussearch transcription factor complexsearch cytosolsearch cytoplasmsearch microtubule organizing centersearch centrosomesearch chromosome, telomeric regionsearch cytoskeletonsearch condensed chromosomesearch Y chromosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch