2r3i Summary

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Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

The structure was published by Fischmann, T.O., Hruza, A., Duca, J.S., et al., Parry, D., Seghezzi, W., and Madison, V., in 2008 in a paper entitled "Structure-guided discovery of cyclin-dependent kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.28 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P24941) chromosome, telomeric regionsearch nucleoplasmsearch cytosolsearch Cajal bodysearch X chromosomesearch endosomesearch centrosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch Y chromosomesearch cytoplasmsearch transcription factor complexsearch nucleussearch condensed chromosomesearch microtubule organizing centersearch protein bindingsearch kinase activitysearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch transferase activitysearch histone kinase activitysearch metal ion bindingsearch potassium ion transportsearch centrosome duplicationsearch mitotic cell cyclesearch regulation of gene silencingsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch G2/M transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of cell proliferationsearch cell divisionsearch histone phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch DNA replicationsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to nitric oxidesearch meiotic nuclear divisionsearch cell cyclesearch mitotic nuclear divisionsearch DNA repairsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch