2r36 Summary


Crystal structure of ni human ARG-insulin

The structure was published by Sreekanth, R., Pattabhi, V., and Rajan, S.S., in 2009 in a paper entitled "Metal induced structural changes observed in hexameric insulin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Insulin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin P01308 (89-110) (INS_HUMAN)search Homo sapienssearch 100% 22 100%
C Insulin P01308 (89-110) (INS_HUMAN)search Homo sapienssearch 100% 22 100%
B Insulin P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
D Insulin P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (89 - 110) Insulin Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C (P01308) PF00049: Insulin/IGF/Relaxin familysearch
B, D (P01308) Isolated insulin B-chainsearch PF00049: Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A, C (P01308) hormone activitysearch extracellular regionsearch
B, D (P01308) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A, C Insulin-likesearch Insulin, conserved sitesearch
B, D Insulinsearch Insulin-likesearch