2r28 Summary

pdbe.org/2r28
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The complex Structure of Calmodulin Bound to a Calcineurin Peptide

The structure was published by Ye, Q., Wang, H., Zheng, J., Wei, Q., and Jia, Z., in 2008 in a paper entitled "The complex structure of calmodulin bound to a calcineurin peptide." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.86 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (1-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 96%
B Calmodulin P62158 (1-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 96%
C Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Q08209 (389-413) (PP2BA_HUMAN)search Homo sapienssearch 100% 25 76%
D Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Q08209 (389-413) (PP2BA_HUMAN)search Homo sapienssearch 100% 25 76%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (1 - 149) Calmodulin Homo sapiens
Q08209 (389 - 413) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P62158) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
C, D (Q08209)

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P62158) calcium ion bindingsearch protein serine/threonine kinase activator activitysearch protein bindingsearch protein domain specific bindingsearch protein kinase bindingsearch nitric-oxide synthase regulator activitysearch phospholipase bindingsearch protein phosphatase activator activitysearch thioesterase bindingsearch nitric-oxide synthase bindingsearch metal ion bindingsearch protein N-terminus bindingsearch type 3 metabotropic glutamate receptor bindingsearch ion channel bindingsearch titin bindingsearch calcium-dependent protein bindingsearch N-terminal myristoylation domain bindingsearch adenylate cyclase bindingsearch enzyme regulator activitysearch phosphatidylinositol 3-kinase bindingsearch plasma membranesearch nucleussearch cytosolsearch nucleoplasmsearch spindle polesearch growth conesearch cytoskeletonsearch cytoplasmsearch neuron projectionsearch extracellular vesicular exosomesearch extracellular regionsearch calcium channel complexsearch sarcomeresearch centrosomesearch spindle microtubulesearch spindlesearch vesiclesearch response to calcium ionsearch detection of calcium ionsearch positive regulation of peptidyl-threonine phosphorylationsearch muscle contractionsearch G-protein coupled receptor signaling pathwaysearch regulation of rhodopsin mediated signaling pathwaysearch activation of adenylate cyclase activitysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of heart ratesearch Fc-epsilon receptor signaling pathwaysearch positive regulation of protein serine/threonine kinase activitysearch rhodopsin mediated signaling pathwaysearch blood coagulationsearch innate immune responsesearch membrane organizationsearch glycogen catabolic processsearch platelet degranulationsearch inositol phosphate metabolic processsearch small molecule metabolic processsearch positive regulation of cyclic nucleotide metabolic processsearch glucose metabolic processsearch epidermal growth factor receptor signaling pathwaysearch activation of phospholipase C activitysearch positive regulation of protein dephosphorylationsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of phosphoprotein phosphatase activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch regulation of cytokinesissearch synaptic transmissionsearch calcium-mediated signalingsearch response to corticosteronesearch fibroblast growth factor receptor signaling pathwaysearch regulation of nitric-oxide synthase activitysearch response to amphetaminesearch regulation of high voltage-gated calcium channel activitysearch positive regulation of nitric-oxide synthase activitysearch signal transductionsearch positive regulation of protein autophosphorylationsearch carbohydrate metabolic processsearch phototransduction, visible lightsearch platelet activationsearch nitric oxide metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch regulation of ryanodine-sensitive calcium-release channel activitysearch substantia nigra developmentsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch negative regulation of peptidyl-threonine phosphorylationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contractionsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C, D