2r28 Summary

pdbe.org/2r28
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The complex Structure of Calmodulin Bound to a Calcineurin Peptide

The structure was published by Ye, Q., Wang, H., Zheng, J., Wei, Q., and Jia, Z., in 2008 in a paper entitled "The complex structure of calmodulin bound to a calcineurin peptide." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.86 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (1-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 96%
B Calmodulin P62158 (1-149) (CALM_HUMAN)search Homo sapienssearch 97% 149 96%
C Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Q08209 (389-413) (PP2BA_HUMAN)search Homo sapienssearch 100% 25 76%
D Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Q08209 (389-413) (PP2BA_HUMAN)search Homo sapienssearch 100% 25 76%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (1 - 149) Calmodulin Homo sapiens
Q08209 (389 - 413) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P62158) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
C, D (Q08209)

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P62158) calcium ion bindingsearch protein bindingsearch phospholipase bindingsearch protein phosphatase activator activitysearch metal ion bindingsearch nitric-oxide synthase bindingsearch protein kinase bindingsearch thioesterase bindingsearch protein N-terminus bindingsearch enzyme regulator activitysearch nitric-oxide synthase regulator activitysearch ion channel bindingsearch N-terminal myristoylation domain bindingsearch protein domain specific bindingsearch titin bindingsearch protein serine/threonine kinase activator activitysearch adenylate cyclase bindingsearch calcium-dependent protein bindingsearch phosphatidylinositol 3-kinase bindingsearch type 3 metabotropic glutamate receptor bindingsearch plasma membranesearch cytosolsearch calcium channel complexsearch cytoplasmsearch sarcomeresearch spindle polesearch nucleoplasmsearch extracellular regionsearch extracellular vesicular exosomesearch growth conesearch cytoskeletonsearch spindle microtubulesearch centrosomesearch nucleussearch spindlesearch vesiclesearch neuron projectionsearch membrane organizationsearch blood coagulationsearch innate immune responsesearch rhodopsin mediated signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch positive regulation of protein serine/threonine kinase activitysearch activation of phospholipase C activitysearch positive regulation of protein dephosphorylationsearch glucose metabolic processsearch epidermal growth factor receptor signaling pathwaysearch positive regulation of cyclic nucleotide metabolic processsearch glycogen catabolic processsearch platelet degranulationsearch inositol phosphate metabolic processsearch small molecule metabolic processsearch regulation of high voltage-gated calcium channel activitysearch positive regulation of phosphoprotein phosphatase activitysearch activation of adenylate cyclase activitysearch positive regulation of nitric-oxide synthase activitysearch regulation of cytokinesissearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch calcium-mediated signalingsearch synaptic transmissionsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of protein autophosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch response to corticosteronesearch response to amphetaminesearch carbohydrate metabolic processsearch phototransduction, visible lightsearch platelet activationsearch nitric oxide metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch regulation of nitric-oxide synthase activitysearch detection of calcium ionsearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch negative regulation of peptidyl-threonine phosphorylationsearch substantia nigra developmentsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch signal transductionsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of rhodopsin mediated signaling pathwaysearch muscle contractionsearch regulation of cardiac muscle contractionsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch response to calcium ionsearch regulation of heart ratesearch G-protein coupled receptor signaling pathwaysearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C, D