2r1t Summary

pdbe.org/2r1t
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dopamine quinone conjugation to DJ-1

A publication describing this structure is not available. The depositing authors are Zhongtao, Z.search; Yue, F.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DJ-1.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DJ-1 Q99497 (2-188) (PARK7_HUMAN)search Homo sapienssearch 99% 187 100%
B DJ-1 Q99497 (2-188) (PARK7_HUMAN)search Homo sapienssearch 99% 187 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (2 - 188) DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch
B (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q99497) cytoplasmsearch cytosolsearch nucleussearch chromatinsearch plasma membranesearch extracellular vesicular exosomesearch membrane raftsearch mitochondrionsearch mitochondrial respiratory chain complex Isearch PML bodysearch membranesearch superoxide dismutase copper chaperone activitysearch cuprous ion bindingsearch glyoxalase III activitysearch peptidase activitysearch protein homodimerization activitysearch enzyme bindingsearch protein bindingsearch ubiquitin-specific protease bindingsearch hydrolase activitysearch RNA bindingsearch tyrosine 3-monooxygenase activator activitysearch small protein activating enzyme bindingsearch peroxidase activitysearch androgen receptor bindingsearch small protein conjugating enzyme bindingsearch core promoter bindingsearch L-dopa decarboxylase activator activitysearch mRNA bindingsearch transcription factor bindingsearch glyoxalase (glycolic acid-forming) activitysearch receptor bindingsearch transcription coactivator activitysearch peroxiredoxin activitysearch single-stranded DNA bindingsearch scaffold protein bindingsearch double-stranded DNA bindingsearch cytokine bindingsearch cupric ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch repressing transcription factor bindingsearch identical protein bindingsearch negative regulation of protein acetylationsearch positive regulation of transcription from RNA polymerase II promotersearch single fertilizationsearch synaptic transmission, dopaminergicsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of protein bindingsearch positive regulation of oxidative phosphorylation uncoupler activitysearch proteolysissearch cell deathsearch regulation of inflammatory responsesearch regulation of androgen receptor signaling pathwaysearch cellular response to oxidative stresssearch response to hydrogen peroxidesearch negative regulation of hydrogen peroxide-induced neuron deathsearch positive regulation of superoxide dismutase activitysearch response to stresssearch negative regulation of protein export from nucleussearch positive regulation of protein localization to nucleussearch methylglyoxal catabolic process to D-lactatesearch negative regulation of death-inducing signaling complex assemblysearch positive regulation of interleukin-8 productionsearch positive regulation of dopamine biosynthetic processsearch cellular response to reactive oxygen speciessearch mitochondrion organizationsearch negative regulation of cell deathsearch negative regulation of neuron apoptotic processsearch regulation of neuron apoptotic processsearch glyoxal catabolic processsearch hydrogen peroxide metabolic processsearch autophagysearch negative regulation of neuron deathsearch negative regulation of apoptotic processsearch adult locomotory behaviorsearch membrane hyperpolarizationsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch regulation of mitochondrial membrane potentialsearch regulation of TRAIL receptor biosynthetic processsearch negative regulation of protein K48-linked deubiquitinationsearch lactate biosynthetic processsearch negative regulation of gene expressionsearch positive regulation of protein homodimerization activitysearch positive regulation of pyrroline-5-carboxylate reductase activitysearch protein stabilizationsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch membrane depolarizationsearch negative regulation of protein ubiquitinationsearch negative regulation of protein kinase activitysearch inflammatory responsesearch negative regulation of protein phosphorylationsearch cellular response to glyoxalsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch oxidation-reduction processsearch cellular response to hydrogen peroxidesearch negative regulation of ubiquitin-specific protease activitysearch glycolate biosynthetic processsearch negative regulation of ubiquitin-protein transferase activitysearch positive regulation of androgen receptor activitysearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of L-dopa biosynthetic processsearch negative regulation of oxidative stress-induced cell deathsearch negative regulation of protein sumoylationsearch positive regulation of L-dopa decarboxylase activitysearch positive regulation of tyrosine 3-monooxygenase activitysearch negative regulation of hydrogen peroxide-induced cell deathsearch dopamine uptake involved in synaptic transmissionsearch
B (Q99497) mitochondrionsearch membranesearch plasma membranesearch extracellular vesicular exosomesearch cytoplasmsearch nucleussearch PML bodysearch membrane raftsearch cytosolsearch mitochondrial respiratory chain complex Isearch chromatinsearch protein bindingsearch transcription factor bindingsearch superoxide dismutase copper chaperone activitysearch peroxidase activitysearch receptor bindingsearch ubiquitin-specific protease bindingsearch cuprous ion bindingsearch enzyme bindingsearch cytokine bindingsearch double-stranded DNA bindingsearch cupric ion bindingsearch transcription coactivator activitysearch glyoxalase III activitysearch peroxiredoxin activitysearch RNA bindingsearch glyoxalase (glycolic acid-forming) activitysearch oxidoreductase activity, acting on peroxide as acceptorsearch scaffold protein bindingsearch peptidase activitysearch repressing transcription factor bindingsearch protein homodimerization activitysearch small protein activating enzyme bindingsearch hydrolase activitysearch L-dopa decarboxylase activator activitysearch single-stranded DNA bindingsearch core promoter bindingsearch identical protein bindingsearch tyrosine 3-monooxygenase activator activitysearch androgen receptor bindingsearch small protein conjugating enzyme bindingsearch mRNA bindingsearch negative regulation of neuron deathsearch negative regulation of cell deathsearch proteolysissearch regulation of androgen receptor signaling pathwaysearch regulation of inflammatory responsesearch cellular response to oxidative stresssearch lactate biosynthetic processsearch regulation of mitochondrial membrane potentialsearch negative regulation of hydrogen peroxide-induced cell deathsearch glyoxal catabolic processsearch positive regulation of tyrosine 3-monooxygenase activitysearch oxidation-reduction processsearch synaptic transmission, dopaminergicsearch positive regulation of pyrroline-5-carboxylate reductase activitysearch glycolate biosynthetic processsearch hydrogen peroxide metabolic processsearch regulation of TRAIL receptor biosynthetic processsearch negative regulation of hydrogen peroxide-induced neuron deathsearch protein stabilizationsearch negative regulation of protein acetylationsearch cellular response to glyoxalsearch positive regulation of L-dopa biosynthetic processsearch positive regulation of L-dopa decarboxylase activitysearch response to stresssearch negative regulation of ubiquitin-protein transferase activitysearch cellular response to hydrogen peroxidesearch positive regulation of protein homodimerization activitysearch single fertilizationsearch mitochondrion organizationsearch negative regulation of death-inducing signaling complex assemblysearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch negative regulation of neuron apoptotic processsearch negative regulation of protein K48-linked deubiquitinationsearch positive regulation of transcription from RNA polymerase II promotersearch adult locomotory behaviorsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch positive regulation of oxidative phosphorylation uncoupler activitysearch negative regulation of protein kinase activitysearch negative regulation of protein bindingsearch negative regulation of oxidative stress-induced cell deathsearch negative regulation of protein ubiquitinationsearch negative regulation of protein phosphorylationsearch negative regulation of protein export from nucleussearch regulation of neuron apoptotic processsearch negative regulation of ubiquitin-specific protease activitysearch positive regulation of dopamine biosynthetic processsearch negative regulation of gene expressionsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of apoptotic processsearch cell deathsearch negative regulation of protein sumoylationsearch positive regulation of protein localization to nucleussearch autophagysearch membrane hyperpolarizationsearch cellular response to reactive oxygen speciessearch methylglyoxal catabolic process to D-lactatesearch positive regulation of interleukin-8 productionsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of superoxide dismutase activitysearch positive regulation of androgen receptor activitysearch response to hydrogen peroxidesearch membrane depolarizationsearch inflammatory responsesearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch dopamine uptake involved in synaptic transmissionsearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch
B ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch