EC 3.5.1.124: Protein deglycase
Reaction catalysed:
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Systematic name:
A [protein]-L-amino acid-1-hydroxypropan-2-one hydrolase ((R)-lactate-forming)
Alternative Name(s):
- DJ-1 protein
- Glyoxylase III
- PARK7 (gene name)
- YajL (gene name)
- YhbO (gene name)
GO terms
Biochemical function:
- glyoxalase (glycolic acid-forming) activity
- ubiquitin-specific protease binding
- cuprous ion binding
- cupric ion binding
- DNA-binding transcription factor binding
- scaffold protein binding
- peroxiredoxin activity
- nuclear androgen receptor binding
- mercury ion binding
- cadherin binding
- protein-containing complex binding
- ubiquitin-like protein conjugating enzyme binding
- small protein activating enzyme binding
- protein homodimerization activity
- identical protein binding
- protein deglycase activity
- L-dopa decarboxylase activator activity
- tyrosine 3-monooxygenase activator activity
- cytokine binding
- kinase binding
- enzyme binding
- oxygen sensor activity
- hydrolase activity
- oxidoreductase activity, acting on peroxide as acceptor
- superoxide dismutase copper chaperone activity
- peptidase activity
- protein binding
- copper ion binding
- signaling receptor binding
- mRNA binding
- RNA binding
- transcription coactivator activity
- single-stranded DNA binding
- double-stranded DNA binding
- core promoter sequence-specific DNA binding
Biological process:
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of androgen receptor activity
- positive regulation of transcription regulatory region DNA binding
- positive regulation of reactive oxygen species metabolic process
- negative regulation of ubiquitin-specific protease activity
- negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
- negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
- positive regulation of autophagy of mitochondrion
- positive regulation of reactive oxygen species biosynthetic process
- negative regulation of reactive oxygen species biosynthetic process
- negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
- regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
- positive regulation of L-dopa decarboxylase activity
- positive regulation of L-dopa biosynthetic process
- glyoxal catabolic process
- glyoxal metabolic process
- positive regulation of dopamine biosynthetic process
- positive regulation of tyrosine 3-monooxygenase activity
- positive regulation of pyrroline-5-carboxylate reductase activity
- negative regulation of TRAIL-activated apoptotic signaling pathway
- negative regulation of protein K48-linked deubiquitination
- negative regulation of death-inducing signaling complex assembly
- positive regulation of mitochondrial electron transport, NADH to ubiquinone
- regulation of supramolecular fiber organization
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- negative regulation of protein acetylation
- positive regulation of superoxide dismutase activity
- positive regulation of protein localization to nucleus
- cellular detoxification of methylglyoxal
- cellular detoxification of aldehyde
- guanine deglycation, glyoxal removal
- guanine deglycation, methylglyoxal removal
- guanine deglycation
- cellular oxidant detoxification
- detection of oxidative stress
- cellular response to hydrogen peroxide
- methylglyoxal catabolic process to lactate
- detoxification of hydrogen peroxide
- regulation of androgen receptor signaling pathway
- membrane hyperpolarization
- membrane depolarization
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of mitochondrial membrane potential
- dopamine uptake involved in synaptic transmission
- negative regulation of ubiquitin-protein transferase activity
- positive regulation of DNA-binding transcription factor activity
- protein stabilization
- detoxification of mercury ion
- regulation of inflammatory response
- negative regulation of protein export from nucleus
- glycolate biosynthetic process
- positive regulation of transcription by RNA polymerase II
- negative regulation of neuron apoptotic process
- regulation of neuron apoptotic process
- hydrogen peroxide metabolic process
- glucose homeostasis
- response to hydrogen peroxide
- negative regulation of protein catabolic process
- glutathione deglycation
- protein deglycation, methylglyoxal removal
- protein deglycation, glyoxal removal
- peptidyl-lysine deglycation
- peptidyl-arginine deglycation
- peptidyl-cysteine deglycation
- cellular response to glyoxal
- cellular response to reactive oxygen species
- cellular response to oxidative stress
- positive regulation of NAD(P)H oxidase activity
- negative regulation of protein sumoylation
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of interleukin-8 production
- regulation of TRAIL production
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- activation of protein kinase B activity
- negative regulation of protein binding
- negative regulation of protein ubiquitination
- positive regulation of protein-containing complex assembly
- insulin secretion
- lactate biosynthetic process
- negative regulation of gene expression
- positive regulation of gene expression
- detoxification of copper ion
- methylglyoxal metabolic process
- adult locomotory behavior
- single fertilization
- Ras protein signal transduction
- mitochondrion organization
- response to oxidative stress
- DNA damage response
- inflammatory response
- autophagy
- protein deglycosylation
- proteolysis
- negative regulation of protein kinase activity
- DNA repair
- positive regulation of acute inflammatory response to antigenic stimulus
- synaptic transmission, dopaminergic
- negative regulation of protein phosphorylation
Cellular component:
- presynapse
- extracellular exosome
- perinuclear region of cytoplasm
- synapse
- membrane raft
- cell body
- neuron projection
- axon
- PML body
- membrane
- adherens junction
- plasma membrane
- cytosol
- endoplasmic reticulum
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
- chromatin
Protein family (Pfam)
InterPro annotations
CATH domain
